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Magyar, Ursula; Stalder, Odile; Baumgartner, Christine; Méan, Marie; Righini, Marc; Schuetz, Philipp; Bassetti, Stefano; Rodondi, Nicolas; Tritschler, Tobias; Aujesky, Drahomir (2024). Association between severity of pulmonary embolism and health-related quality of life. Journal of thrombosis and haemostasis, 22(2), pp. 516-525. Elsevier 10.1016/j.jtha.2023.10.016
Gaugler, Jan O; Righini, Marc; Robert-Ebadi, Helia; Sanchez, Olivier; Roy, Pierre-Marie; Verschuren, Franck; Miranda, Sebastien; Delluc, Aurélien; Le Gal, Grégoire; Tritschler, Tobias (2024). Obesity as a Predictor for Pulmonary Embolism and Performance of the Age-Adjusted D-Dimer Strategy in Obese Patients with Suspected Pulmonary Embolism. Thrombosis and haemostasis, 124(1), pp. 49-57. Thieme 10.1055/s-0043-57018
Deschamps, Justine; Choffat, Damien; Limacher, Andreas; Righini, Marc; Beer, Juerg Hans; Baumgartner, Christine; Hugli, Olivier; Aujesky, Drahomir; Mean, Marie (2023). Quality of Life in elderly patients with venous thromboembolism assessed using Patient-Reported Outcome Measures. Journal of thrombosis and haemostasis, 21(11), pp. 3193-3202. Elsevier 10.1016/j.jtha.2023.07.022
Villiger, Rahel; Méan, Marie; Stalder, Odile; Limacher, Andreas; Rodondi, Nicolas; Righini, Marc; Aujesky, Drahomir (2023). Prediction of very early major bleeding risk in acute pulmonary embolism: an independent external validation of the PE-SARD Bleeding Score. Journal of thrombosis and haemostasis, 21(10), pp. 2884-2893. Elsevier 10.1016/j.jtha.2023.04.025
Barco, Stefano; Virdone, Saverio; Götschi, Andrea; Ageno, Walter; Arcelus, Juan I; Bingisser, Roland; Colucci, Giuseppe; Cools, Frank; Duerschmied, Daniel; Gibbs, Harry; Fumagalli, Riccardo M; Gerber, Bernhard; Haas, Sylvia; Himmelreich, Jelle C L; Hobbs, Richard; Hobohm, Lukas; Jacobson, Barry; Kayani, Gloria; Lopes, Renato D; MacCallum, Peter; ... (2023). Enoxaparin for symptomatic COVID-19 managed in the ambulatory setting: An individual patient level analysis of the OVID and ETHIC trials. Thrombosis research, 230, pp. 27-32. Elsevier 10.1016/j.thromres.2023.08.009
Vrotniakaite-Bajerciene, Kristina; Rütsche, Sereina; Calzavarini, Sara; Quarroz, Claudia; Stalder, Odile; Marie, Méan; Righini, Marc; Staub, Daniel; Beer, Juerg H; Frauchiger, Beat; Osterwalder, Joseph; Kucher, Nils; Matter, Christian M; Husmann, Marc; Banyai, Martin; Aschwanden, Markus; Mazzolai, Lucia; Hugli, Olivier; Rodondi, Nicolas; Aujesky, Drahomir; ... (2023). Thrombin Generation Is Associated with Venous Thromboembolism Recurrence, but Not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study. Journal of clinical medicine, 12(18), p. 6050. MDPI 10.3390/jcm12186050
Voci, Davide; Fedeli, Ugo; Valerio, Luca; Schievano, Elena; Righini, Marc; Kucher, Nils; Spirk, David; Barco, Stefano (2023). Mortality rate related to peripheral arterial disease: A retrospective analysis of epidemiological data (years 2008-2019). Nutrition, metabolism, and cardiovascular diseases : NMCD, 33(3), pp. 516-522. Elsevier 10.1016/j.numecd.2022.11.020
Stals, Milou A M; Moumneh, Thomas; Ainle, Fionnuala Ni; Aujesky, Drahomir; van Bemmel, Thomas; Bertoletti, Laurent; Bistervels, Ingrid M; Chauleur, Céline; Couturaud, Francis; van Dooren, Yordi P A; Elias, Antoine; Faber, Laura M; Le Gall, Catherine; Hofstee, Herman M A; van der Hulle, Tom; Kruip, Marieke J H A; Maignan, Maxime; Mairuhu, Albert T A; Middeldorp, Saskia; Le Moigne, Emmanuelle; ... (2023). Noninvasive diagnostic work-up for suspected acute pulmonary embolism during pregnancy: a systematic review and meta-analysis of individual patient data. Journal of thrombosis and haemostasis, 21(3), pp. 606-615. Wiley-Blackwell 10.1016/j.jtha.2022.11.025
Schenker, Carla; Stalder, Odile; Méan, Marie; Tritschler, Tobias; Righini, Marc; Rodondi, Nicolas; Aujesky, Drahomir (2023). Bleeding Risk in Elderly Patients with Venous Thromboembolism Who Would Have Been Excluded from Anticoagulation Trials. Thrombosis and haemostasis, 123(4), pp. 427-437. Thieme 10.1055/s-0042-1760365
Voci, Davide; Götschi, Andrea; Held, Ulrike; Bingisser, Roland; Colucci, Giuseppe; Duerschmied, Daniel; Fumagalli, Riccardo M; Gerber, Bernhard; Hasse, Barbara; Keller, Dagmar I; Konstantinides, Stavros V; Mach, François; Rampini, Silvana K; Righini, Marc; Robert-Ebadi, Helia; Rosemann, Thomas; Roth-Zetzsche, Stéphanie; Sebastian, Tim; Simon, Noemi R; Spirk, David; ... (2023). Enoxaparin for outpatients with COVID-19: 90-day results from the randomised, open-label, parallel-group, multinational, phase III OVID trial. Thrombosis research, 221, pp. 157-163. Elsevier 10.1016/j.thromres.2022.10.021
Righini, Marc; Robert-Ebadi, Helia; Cremonesi, Alessio; Elias, Antoine; Sanchez, Olivier; Le Moigne, Emmanuelle; Schmidt, Jeannot; Le Gall, Catherine; Cornuz, Jacques; Aujesky, Drahomir; Roy, Pierre-Marie; Chauleur, Céline; Rouyer, Frédéric; Poletti, Pierre-Alexandre; Moreau, Caroline; Le Gal, Grégoire (2022). Risk of neonatal hypothyroidism in newborns from mothers exposed to CTPA during pregnancy: ancillary data from a prospective outcome study. Journal of thrombosis and haemostasis, 20(11), pp. 2550-2555. Wiley-Blackwell 10.1111/jth.15843
Messi, Mia; Beneyto Afonso, Carlota; Stalder, Odile; Méan, Marie; Righini, Marc; Rodondi, Nicolas; Aujesky, Drahomir (2022). Long-term clinical outcomes in older patients with acute venous thromboembolism who have renal impairment. Thrombosis research, 218, pp. 64-71. Elsevier 10.1016/j.thromres.2022.08.001
Barco, Stefano; Voci, Davide; Held, Ulrike; Sebastian, Tim; Bingisser, Roland; Colucci, Giuseppe; Duerschmied, Daniel; Frenk, André; Gerber, Bernhard; Götschi, Andrea; Konstantinides, Stavros V; Mach, François; Robert-Ebadi, Helia; Rosemann, Thomas; Simon, Noemi R; Spechbach, Hervé; Spirk, David; Stortecky, Stefan; Vaisnora, Lukas; Righini, Marc; ... (2022). Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial. The Lancet. Haematology, 9(8), e585-e593. Elsevier 10.1016/S2352-3026(22)00175-2
Robert-Ebadi, Helia; Elias, Antoine; Sanchez, Olivier; Le Moigne, Emmanuelle; Schmidt, Jeannot; Le Gall, Catherine; Aujesky, Drahomir; Roy, Pierre-Marie; Moumneh, Thomas; Chauleur, Céline; Rouyer, Frederic; Le Gal, Grégoire; Righini, Marc (2021). Assessing the clinical probability of pulmonary embolism during pregnancy: The Pregnancy-Adapted Geneva (PAG) score. Journal of thrombosis and haemostasis, 19(12), pp. 3044-3050. Wiley-Blackwell 10.1111/jth.15521
Blondon, Marc; Limacher, Andreas; Righini, Marc; Aujesky, Drahomir; Méan, Marie (2021). Underuse of medical thromboprophylaxis in mobile elderly inpatients: The SWITCO65+ cohort. Research and practice in thrombosis and haemostasis, 5(1), pp. 142-147. Wiley 10.1002/rth2.12361
Baumgartner, Christine; Klok, Frederikus A; Carrier, Marc; Limacher, Andreas; Moor, Jeanne; Righini, Marc; Beer, Jürg-Hans; Peluso, Martina; Rakovic, Damiana; Huisman, Menno V; Aujesky, Drahomir (2020). Clinical Surveillance vs. Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism: protocol for a multicentre randomised placebo-controlled non-inferiority trial (SAFE-SSPE). BMJ open, 10(11), e040151. BMJ Publishing Group 10.1136/bmjopen-2020-040151
Barco, Stefano; Bingisser, Roland; Colucci, Giuseppe; Frenk, André; Gerber, Bernhard; Held, Ulrike; Mach, Francois; Mazzolai, Lucia; Righini, Marc; Rosemann, Thomas; Sebastian, Tim; Spescha, Rebecca; Stortecky, Stefan; Windecker, Stephan; Kucher, Nils (2020). Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial. Trials, 21(1), p. 770. BioMed Central 10.1186/s13063-020-04678-4
Tritschler, Tobias; Kraaijpoel, Noémie; Langlois, Nicole; Girard, Philippe; Schulman, Sam; Büller, Harry R; Segers, Annelise; Righini, Marc; Le Gal, Grégoire (2020). Development of a standardized definition of pulmonary embolism-related death: a cross-sectional survey of international thrombosis experts. Journal of thrombosis and haemostasis, 18(6), pp. 1415-1420. Wiley-Blackwell 10.1111/jth.14775
Tritschler, Tobias; Kraaijpoel, Noémie; Girard, Philippe; Büller, Harry R; Langlois, Nicole; Righini, Marc; Schulman, Sam; Segers, Annelise; Le Gal, Grégoire (2020). Definition of pulmonary embolism-related death and classification of the cause of death in venous thromboembolism studies: Communication from the SSC of the ISTH. Journal of thrombosis and haemostasis, 18(6), pp. 1495-1500. Wiley-Blackwell 10.1111/jth.14769
Mathis, Alexandra; Villiger, Lukas; Reiner, Martin F; Egloff, Michael; Schmid, Hans Ruedi; Stivala, Simona; Limacher, Andreas; Méan, Marie; Aujesky, Drahomir; Rodondi, Nicolas; Angelillo, Anne; Righini, Marc; Staub, Daniel; Aschwanden, Markus; Frauchiger, Beat; Osterwalder, Joseph; Kucher, Nils; Matter, Christian M; Banyai, Martin; Hugli, Oliver; ... (2020). Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality- the SWEETCO 65+ study. Scientific Reports, 10(1), p. 2495. Nature Publishing Group 10.1038/s41598-020-59173-2
Simona, Aurélien; Limacher, Andreas; Méan, Marie; Golaz, Olivier; Bounameaux, Henri; Aujesky, Drahomir; Righini, Marc; Vuilleumier, Nicolas (2020). High-sensitive cardiac troponin T as a marker of hemorrhagic complications in elderly patients anticoagulated for non-massive pulmonary embolism. Thrombosis research, 185, pp. 5-12. Elsevier 10.1016/j.thromres.2019.11.006
Stoller, Nina; Limacher, Andreas; Méan Pascual, Marie; Baumgartner, Christine; Tritschler, Tobias; Righini, Marc; Beer, Jürg-Hans; Rodondi, Nicolas; Aujesky, Drahomir (2019). Clinical presentation and outcomes in elderly patients with symptomatic isolated subsegmental pulmonary embolism. Thrombosis research, 184, pp. 24-30. Elsevier 10.1016/j.thromres.2019.10.008
Klingenberg, Roland; Schlager, Oliver; Limacher, Andreas; Méan, Marie; Vuilleumier, Nicolas; Beer, Juerg H; Staub, Daniel; Frauchiger, Beat; Aschwanden, Markus; Lämmle, Bernhard; Righini, Marc; Egloff, Michael; Osterwalder, Joseph; Angelillo, Anne; Kucher, Nils; Banyai, Martin; Rodondi, Nicolas; von Eckardstein, Arnold; Aujesky, Drahomir; Husmann, Marc; ... (2019). Risk stratification of elderly patients with acute pulmonary embolism. European journal of clinical investigation EJCI, 49(9), e13154. Wiley-Blackwell 10.1111/eci.13154
Righini, Marc; Robert-Ebadi, Helia; Elias, Antoine; Sanchez, Olivier; Le Moigne, Emmanuelle; Schmidt, Jeannot; Le Gall, Catherine; Cornuz, Jacques; Aujesky, Drahomir; Roy, Pierre-Marie; Chauleur, Céline; Rutschmann, Olivier T; Poletti, Pierre-Alexandre; Le Gal, Grégoire (2018). Diagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study. Annals of internal medicine, 169(11), pp. 766-773. American College of Physicians 10.7326/M18-1670
Lauber, Sandro; Limacher, Andreas; Tritschler, Tobias; Stalder, Odile; Méan, Marie; Righini, Marc; Aschwanden, Markus; Beer, Jürg Hans; Frauchiger, Beat; Osterwalder, Josef; Kucher, Nils; Lämmle, Bernhard; Cornuz, Jacques; Angelillo-Scherrer, Anne; Matter, Christian M; Husmann, Marc; Banyai, Martin; Staub, Daniel; Mazzolai, Lucia; Hugli, Olivier; ... (2018). Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients. American journal of medicine, 131(6), 703.e7-703.e16. Elsevier 10.1016/j.amjmed.2017.12.015
Blondon, Marc; Spirk, David; Kucher, Nils; Aujesky, Drahomir; Hayoz, Daniel; Beer, Jürg H; Husmann, Marc; Frauchiger, Beat; Korte, Wolfgang; Wuillemin, Walter Alfred; Bounameaux, Henri; Righini, Marc; Nendaz, Mathieu (2018). Comparative Performance of Clinical Risk Assessment Models for Hospital-Acquired Venous Thromboembolism in Medical Patients. Thrombosis and haemostasis, 118(1), pp. 82-89. Schattauer 10.1160/TH17-06-0403
Seiler, Eva; Limacher, Andreas; Méan, Marie; Beer, Hans-Jürg; Osterwalder, Joseph; Frauchiger, Beat; Righini, Marc; Aschwanden, Markus; Matter, Christian M; Banyai, Martin; Kucher, Nils; Staub, Daniel; Lämmle, Bernhard; Rodondi, Nicolas; Squizzato, Alessandro; Aujesky, Drahomir (2017). Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation. Thrombosis and haemostasis, 117(10), pp. 1930-6. Schattauer 10.1160/TH-17-03-0162
Faller, Nicolas; Limacher, Andreas; Méan, Marie; Righini, Marc; Aschwanden, Markus; Beer, Jürg Hans; Frauchiger, Beat; Osterwalder, Josef; Kucher, Nils; Lämmle, Bernhard; Cornuz, Jacques; Angelillo-Scherrer, Anne; Matter, Christian M.; Husmann, Marc; Banyai, Martin; Staub, Daniel; Mazzolai, Lucia; Hugli, Olivier; Rodondi, Nicolas and Aujesky, Drahomir (2017). Predictors and Causes of Long-Term Mortality in Elderly Patients with Acute Venous Thromboembolism: A Prospective Cohort Study. American journal of medicine, 130(2), pp. 198-206. Elsevier 10.1016/j.amjmed.2016.09.008
Hofmann, Eveline; Limacher, Andreas; Méan, Marie; Kucher, Nils; Righini, Marc; Frauchiger, Beat; Beer, Jürg-Hans; Osterwalder, Joseph; Aschwanden, Markus; Matter, Christian M; Banyai, Martin; Egloff, Michael; Hugli, Olivier; Staub, Daniel; Bounameaux, Henri; Rodondi, Nicolas; Aujesky, Drahomir (2016). Echocardiography does not predict mortality in hemodynamically stable elderly patients with acute pulmonary embolism. Thrombosis research, 145, pp. 67-71. Elsevier 10.1016/j.thromres.2016.07.014
Vuilleumier, Nicolas; Simona, Aurélien; Méan, Marie; Limacher, Andreas; Lescuyer, Pierre; Gerstel, Eric; Bounameaux, Henri; Aujesky, Drahomir; Righini, Marc (2016). Comparison of Cardiac and Non-Cardiac Biomarkers for Risk Stratification in Elderly Patients with Non-Massive Pulmonary Embolism. PLoS ONE, 11(5), e0155973. Public Library of Science 10.1371/journal.pone.0155973
Insam, Charlène Johanna; Méan Pascual, Marie; Limacher, Andreas; Angelillo, Anne; Aschwanden, Markus; Banyai, Martin; Beer, Juerg-Hans; Bounameaux, Henri; Egloff, Michael; Frauchiger, Beat; Husmann, Marc; Kucher, Nils; Lämmle, Bernhard; Matter, Christian; Osterwalder, Joseph; Righini, Marc; Staub, Daniel; Rodondi, Nicolas; Aujesky, Drahomir (2016). Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study. PLoS ONE, 11(2), e0148348. Public Library of Science 10.1371/journal.pone.0148348
Segna, Daniel; Méan, Marie; Limacher, Andreas; Baumgartner, Christine; Blum, Manuel R; Beer, Jürg-Hans; Kucher, Nils; Righini, Marc; Matter, Christian M; Frauchiger, Beat; Cornuz, Jacques; Aschwanden, Markus; Banyai, Martin; Osterwalder, Joseph; Husmann, Marc; Egloff, Michael; Staub, Daniel; Lämmle, Bernhard; Angelillo, Anne; Aujesky, Drahomir; ... (2016). Association between thyroid dysfunction and venous thromboembolism in the elderly: a prospective cohort study. Journal of thrombosis and haemostasis, 14(4), pp. 685-694. Wiley-Blackwell 10.1111/jth.13276
Leiss, Waltraud; Méan, Marie; Limacher, Andreas; Righini, Marc; Jaeger, Kurt; Beer, Hans-Jürg; Osterwalder, Joseph; Frauchiger, Beat; Matter, Christian M; Kucher, Nils; Angelillo, Anne; Cornuz, Jacques; Banyai, Martin; Lämmle, Bernhard; Husmann, Marc; Egloff, Michael; Aschwanden, Markus; Rodondi, Nicolas; Aujesky, Drahomir (2015). Polypharmacy is Associated with an Increased Risk of Bleeding in Elderly Patients with Venous Thromboembolism. Journal of general internal medicine, 30(1), pp. 17-24. Springer 10.1007/s11606-014-2993-8
Frey, P M; Méan, M; Limacher, A; Jaeger, Kurt; Beer, Hans-Jürg; Frauchiger, Beat; Aschwanden, Markus; Rodondi, N; Righini, Marc; Egloff, Michael; Osterwalder, Joseph; Kucher, N; Angelillo, Anne; Husmann, Marc; Banyai, Martin; Matter, Christian M; Aujesky, D (2015). Physical Activity and Risk of Bleeding in Elderly Patients Taking Anticoagulants. Journal of thrombosis and haemostasis, 13(2), pp. 197-205. Wiley-Blackwell 10.1111/jth.12793
Rodger, Marc A.; Le Gal, Gregoire; Wells, Philip; Baglin, Trevor; Aujesky, Drahomir; Righini, Marc; Palareti, Gualtiero; Huisman, Menno; Meyer, Guy (2014). Clinical decision rules and D-Dimer in venous thromboembolism: current controversies and future research priorities. Thrombosis research, 134(4), pp. 763-768. Elsevier 10.1016/j.thromres.2014.07.031
Kleinjan, Ankie; Di Nisio, Marcello; Beyer-Westendorf, Jan; Camporese, Giuseppe; Cosmi, Benilde; Ghirarduzzi, Angelo; Kamphuisen, Pieter W.; Otten, Hans-Martin; Porreca, Ettore; Aggarwal, Anita; Brodmann, Marianne; Guglielmi, Maria Domenica; Iotti, Matteo; Kaasjager, Karin; Kamvissi, Virginia; Lerede, Teresa; Marschang, Peter; Meijer, Karina; Palareti, Gualtiero; Rickles, Frederick R.; ... (2014). Safety and Feasibility of a Diagnostic Algorithm Combining Clinical Probability, d-Dimer Testing, and Ultrasonography for Suspected Upper Extremity Deep Venous Thrombosis: A Prospective Management Study. Annals of internal medicine, 160(7), pp. 451-7. American College of Physicians 10.7326/M13-2056
Stuck, Anna K.; Stone, Roslyn A.; Pugh, Nathan; Righini, Marc; Yealy, Donald M.; Aujesky, Drahomir (2014). Comparison of the Pulmonary Embolism Severity Index to a simplified version: classification and clinical outcomes. Thrombosis research, 133(3), pp. 515-516. Elsevier 10.1016/j.thromres.2013.12.012
Stuck, Anna K.; Méan Pascual, Marie; Limacher, Andreas; Righini, Marc; Jaeger, Kurt; Beer, Hans-Jürg; Osterwalder, Joseph; Frauchiger, Beat; Matter, Christian M.; Kucher, Nils; Egloff, Michael; Aschwanden, Markus; Husmann, Marc; Angelillo-Scherrer, Anne; Rodondi, Nicolas; Aujesky, Drahomir (2014). The adherence to initial processes of care in elderly patients with acute venous thromboembolism. PLoS ONE, 9(7), e100164. Public Library of Science 10.1371/journal.pone.0100164
Bertoletti, Laurent; Le Gal, Grégoire; Aujesky, Drahomir; Sanchez, Olivier; Roy, Pierre-Marie; Verschuren, Franck; Bounameaux, Henri; Perrier, Arnaud; Righini, Marc (2013). Prognostic value of the Geneva prediction rule in patients with pulmonary embolism. Thrombosis research, 132(1), pp. 32-36. Elsevier 10.1016/j.thromres.2013.05.001
Méan, Marie; Righini, Marc; Jaeger, Kurt; Beer, Hans-Jürg; Frauchiger, Beat; Osterwalder, Joseph; Kucher, Nils; Lämmle, Bernhard; Cornuz, Jacques; Angelillo, Anne; Rodondi, Nicolas; Limacher, Andreas; Trelle, Sven; Matter, Christian M.; Husmann, Marc; Banyai, Martin; Aschwanden, Markus; Egloff, Michael; Mazzolai, Lucia; Hugli, Olivier; ... (2013). The Swiss cohort of elderly patients with venous thromboembolism (SWITCO65+): rationale and methodology. Journal of thrombosis and thrombolysis, 36(4), pp. 475-483. New York, N.Y.: Springer 10.1007/s11239-013-0875-2
Blondon, Marc; Righini, Marc; Aujesky, Drahomir; Le Gal, Grégoire; Perrier, Arnaud (2012). Usefulness of preemptive anticoagulation in patients with suspected pulmonary embolism: a decision analysis. Chest, 142(3), pp. 697-703. Northbrook, Ill.: American College of Chest Physicians 10.1378/chest.11-2694
Aujesky, Drahomir; Roy, Pierre-Marie; Verschuren, Franck; Righini, Marc; Osterwalder, Joseph; Egloff, Michael; Renaud, Bertrand; Verhamme, Peter; Stone, Roslyn A; Legall, Catherine; Sanchez, Olivier; Pugh, Nathan A; N'gako, Alfred; Cornuz, Jacques; Hugli, Olivier; Beer, Hans-Jürg; Perrier, Arnaud; Fine, Michael J; Yealy, Donald M (2011). Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial. Lancet, 378(9785), pp. 41-8. London: Elsevier 10.1016/S0140-6736(11)60824-6
