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Krolicki, Leszek; Kunikowska, Jolanta; Cordier, Dominik; Slavova, Nedelina; Koziara, Henryk; Bruchertseifer, Frank; Maecke, Helmut R; Morgenstern, Alfred; Merlo, Adrian (2023). Long-Term Tumor Control Following Targeted Alpha Therapy (TAT) of Low-Grade Gliomas (LGGs): A New Treatment Paradigm? International journal of molecular sciences, 24(21) MDPI 10.3390/ijms242115701
Abiraj, Keelara; Ursillo, Samer; Tamma, Maria Luisa; Rylova, Svetlana N; Waser, Beatrice; Constable, Edwin C; Fani, Melpomeni; Nicolas, Guillaume P; Reubi, Jean Claude; Maecke, Helmut R (2018). The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist. EJNMMI research, 8(1), p. 75. Springer 10.1186/s13550-018-0428-y
Nicolas, Guillaume P; Beykan, Seval; Bouterfa, Hakim; Kaufmann, Jens; Bauman, Andreas; Lassmann, Michael; Reubi, Jean Claude; Rivier, Jean E F; Maecke, Helmut R; Fani, Melpomeni; Wild, Damian (2018). Safety, Biodistribution, and Radiation Dosimetry of Ga-OPS202 in Patients with Gastroenteropancreatic Neuroendocrine Tumors: A Prospective Phase I Imaging Study. Journal of nuclear medicine, 59(6), pp. 909-914. Society of Nuclear Medicine 10.2967/jnumed.117.199737
Umlauft, Maria; Radojewski, Piotr; Spanjol, Petar Marko; Dumont, Rebecca; Marincek, Nicolas; Kollár, Attila; Brunner, Philippe; Beyersmann, Jan; Müller-Brand, Jan; Maecke, Helmut R; Laimer, Markus; Walter, Martin Alexander (2017). Reply: Diabetes Mellitus and Its Effects on All-Cause Mortality After Radiopeptide Therapy for Neuroendocrine Tumors: Methodologic Issues. Journal of nuclear medicine, 58(9), p. 1532. Society of Nuclear Medicine 10.2967/jnumed.117.190660
Brunner, Philippe; Jörg, Ann-Catherine; Glatz, Katharina; Bubendorf, Lukas; Radojewski, Piotr; Umlauft, Maria; Marincek, Nicolas; Spanjol, Petar Marko; Krause, Thomas Michael; Dumont, Rebecca A; Maecke, Helmut R; Müller-Brand, Jan; Briel, Matthias; Schmitt, Anja; Perren, Aurel; Walter, Martin Alexander (2017). The prognostic and predictive value of sstr2-immunohistochemistry and sstr2-targeted imaging in neuroendocrine tumors. European journal of nuclear medicine and molecular imaging, 44(3), pp. 468-475. Springer 10.1007/s00259-016-3486-2
Popp, Ilinca; Del Pozzo, Luigi; Waser, Beatrice; Reubi, Jean Claude; Meyer, Philipp T; Maecke, Helmut R; Gourni, Eleni (2017). Approaches to improve metabolic stability of a statine-based GRP receptor antagonist. Nuclear medicine and biology, 45, pp. 22-29. Elsevier 10.1016/j.nucmedbio.2016.11.004
Läppchen, Tilman; Tönnesmann, Roswitha; Eersels, Jos; Meyer, Philipp T; Maecke, Helmut R; Rylova, Svetlana N (2017). Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake. PLoS ONE, 12(1), e0170435. Public Library of Science 10.1371/journal.pone.0170435
Radojewski, Piotr; Dumont, Rebecca A; Marincek, Nicolas; Brunner, Philippe; Müller-Brand, Jan; Maecke, Helmut R; Briel, Matthias; Walter, Martin Alexander (2016). Reply: Somatostatin Receptor-Targeted Radiopeptide Therapy in Patients with Progressive Unresectable Meningioma. Journal of nuclear medicine, 57(10), pp. 1657-1658. Society of Nuclear Medicine 10.2967/jnumed.116.178145
Reubi, Jean Claude; Waser, Beatrice; Maecke, Helmut R; Rivier, Jean E (2016). HIGHLY INCREASED 125I-JR11 ANTAGONIST BINDING IN VITRO REVEALS NOVEL INDICATIONS FOR SST2 TARGETING IN HUMAN CANCERS. Journal of nuclear medicine, 58(2), pp. 300-306. Society of Nuclear Medicine 10.2967/jnumed.116.177733
Rylova, Svetlana N; Waser, Beatrice; Del Pozzo, Luigi; Tönnesmann, Roswitha; Mansi, Rosalba; Meyer, Philipp T; Reubi, Jean Claude; Maecke, Helmut R (2016). Approaches to Improve the Pharmacokinetics of Radiolabeled Glucagon-Like Peptide-1 Receptor Ligands Using Antagonistic Tracers. Journal of nuclear medicine, 57(8), pp. 1282-1288. Society of Nuclear Medicine 10.2967/jnumed.115.168948
Gourni, Eleni; Del Pozzo, Luigi; Kheirallah, Emilie; Smerling, Christiane; Waser, Beatrice; Reubi, Jean-Claude; Paterson, Brett M; Donnelly, Paul S; Meyer, Philipp T; Maecke, Helmut R (2015). Copper-64 Labeled Macrobicyclic Sarcophagine Coupled to a GRP Receptor Antagonist Shows Great Promise for PET Imaging of Prostate Cancer. Molecular Pharmaceutics, 12(8), pp. 2781-2790. American Chemical Society 10.1021/mp500671j
Kolenc Peitl, Petra; Tamma, MariaLuisa; Kroselj, Marko; Braun, Friederike; Waser, Beatrice; Reubi, Jean Claude; Sollner Dolenc, Marija; Maecke, Helmut R; Mansi, Rosalba (2015). Stereochemistry of Amino Acid Spacers Determines the Pharmacokinetics of (111)In-DOTA-Minigastrin Analogues for Targeting the CCK2/Gastrin Receptor. Bioconjugate chemistry, 26(6), pp. 1113-1119. American Chemical Society 10.1021/acs.bioconjchem.5b00187
Mansi, Rosalba; Abiraj, Keelara; Wang, Xuejuan; Tamma, Maria Luisa; Gourni, Eleni; Cescato, Renzo; Berndt, Sandra; Reubi, Jean Claude; Maecke, Helmut R (2015). Evaluation of three different families of bombesin receptor radioantagonists for targeted imaging and therapy of gastrin releasing peptide receptor (GRP-R) positive tumors. Journal of medicinal chemistry, 58(2), pp. 682-691. American Chemical Society 10.1021/jm5012066
Dumont, Rebecca A; Seiler, Daniela; Marincek, Nicolas; Brunner, Philippe; Radojewski, Piotr; Rochlitz, Christoph; Müller-Brand, Jan; Maecke, Helmut R; Briel, Matthias; Walter, Martin Alexander (2015). Survival after somatostatin based radiopeptide therapy with (90)Y-DOTATOC vs. (90)Y-DOTATOC plus (177)Lu-DOTATOC in metastasized gastrinoma. American journal of nuclear medicine and molecular imaging, 5(1), pp. 46-55.
Gourni, Eleni; Mansi, Rosalba; Jamous, Mazen; Waser, Beatrice; Smerling, Christiane; Burian, Antje; Buchegger, Franz; Reubi, Jean-Claude; Maecke, Helmut R (2014). N-terminal modifications improve the receptor affinity and pharmacokinetics of radiolabeled peptidic gastrin-releasing peptide receptor antagonists: examples of 68Ga- and 64Cu-labeled peptides for PET imaging. Journal of nuclear medicine, 55(10), pp. 1719-1725. Society of Nuclear Medicine 10.2967/jnumed.114.141242
Jamous, Mazen; Tamma, Maria L; Gourni, Eleni; Waser, Beatrice; Reubi, Jean-Claude; Maecke, Helmut R; Mansi, Rosalba (2014). PEG spacers of different length influence the biological profile of bombesin-based radiolabeled antagonists. Nuclear medicine and biology, 41(6), pp. 464-470. Elsevier 10.1016/j.nucmedbio.2014.03.014
Wild, Damian; Fani, Melpomeni; Fischer, Richard; Del Pozzo, Luigi; Kaul, Felix; Krebs, Simone; Fischer, Richard; Rivier, Jean E F; Reubi, Jean-Claude; Maecke, Helmut R; Weber, Wolfgang A (2014). Comparison of Somatostatin Receptor Agonist and Antagonist for Peptide Receptor Radionuclide Therapy: A Pilot Study. Journal of nuclear medicine, 55(8), pp. 1248-1252. Society of Nuclear Medicine 10.2967/jnumed.114.138834
Gourni, Eleni; Waser, Beatrice; Clerc, Pascal; Fourmy, Daniel; Reubi, Jean-Claude; Maecke, Helmut R (2014). The Glucose-Dependent Insulinotropic Polypeptide Receptor: A Novel Target for Neuroendocrine Tumor Imaging-First Preclinical Studies. Journal of nuclear medicine, 55(6), pp. 976-982. Society of Nuclear Medicine 10.2967/jnumed.113.133744
Wieser, Gesche; Mansi, Rosalba; Grosu, Anca L; Schultze-Seemann, Wolfgang; Dumont-Walter, Rebecca A; Meyer, Philipp T; Maecke, Helmut R; Reubi, Jean-Claude; Weber, Wolfgang A (2014). Positron emission tomography (PET) imaging of prostate cancer with a gastrin releasing peptide receptor antagonist - from mice to men. Theranostics, 4(4), pp. 412-419. Ivyspring International 10.7150/thno.7324
Wang, Xuejuan; Fani, Melpomeni; Schulz, Stefan; Rivier, Jean; Reubi, Jean-Claude; Maecke, Helmut R (2012). Comprehensive evaluation of a somatostatin-based radiolabelled antagonist for diagnostic imaging and radionuclide therapy. European journal of nuclear medicine and molecular imaging, 39(12), pp. 1876-85. Berlin: Springer 10.1007/s00259-012-2231-8
Fani, Melpomeni; Braun, Friederike; Waser, Beatrice; Beetschen, Karin; Cescato, Renzo; Erchegyi, Judit; Rivier, Jean E; Weber, Wolfgang A; Maecke, Helmut R; Reubi, Jean-Claude (2012). Unexpected sensitivity of sst2 antagonists to N-terminal radiometal modifications. Journal of nuclear medicine, 53(9), pp. 1481-9. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.112.102764
Mansi, Rosalba; Wang, Xuejuan; Forrer, Flavio; Waser, Beatrice; Cescato, Renzo; Graham, Keith; Borkowski, Sandra; Reubi, Jean-Claude; Maecke, Helmut R (2011). Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours. European journal of nuclear medicine and molecular imaging, 38(1), pp. 97-107. Berlin: Springer 10.1007/s00259-010-1596-9
Abiraj, Keelara; Mansi, Rosalba; Tamma, Maria-Luisa; Fani, Melpomeni; Forrer, Flavio; Nicolas, Guillaume; Cescato, Renzo; Reubi, Jean-Claude; Maecke, Helmut R (2011). Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors. Journal of nuclear medicine, 52(12), pp. 1970-8. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.111.094375
Wild, Damian; Fani, Melpomeni; Behe, Martin; Brink, Ingo; Rivier, Jean E F; Reubi, Jean-Claude; Maecke, Helmut R; Weber, Wolfgang A (2011). First clinical evidence that imaging with somatostatin receptor antagonists is feasible. Journal of nuclear medicine, 52(9), pp. 1412-7. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.111.088922
Fani, Melpomeni; Del Pozzo, Luigi; Abiraj, Keelara; Mansi, Rosalba; Tamma, Maria Luisa; Cescato, Renzo; Waser, Beatrice; Weber, Wolfgang A; Reubi, Jean-Claude; Maecke, Helmut R (2011). PET of somatostatin receptor-positive tumors using 64Cu- and 68Ga-somatostatin antagonists: the chelate makes the difference. Journal of nuclear medicine, 52(7), pp. 1110-8. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.111.087999
Maecke, Helmut R; Reubi, Jean-Claude (2011). Somatostatin receptors as targets for nuclear medicine imaging and radionuclide treatment. Journal of nuclear medicine, 52(6), pp. 841-4. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.110.084236
Kolenc-Peitl, Petra; Mansi, Rosalba; Tamma, MariaLuisa; Gmeiner-Stopar, Tanja; Sollner-Dolenc, Marija; Waser, Beatrice; Baum, Richard P; Reubi, Jean-Claude; Maecke, Helmut R (2011). Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor. Journal of medicinal chemistry, 54(8), pp. 2602-9. Easton, Pa.: American Chemical Society 10.1021/jm101279a
Wild, Damian; Frischknecht, Michael; Zhang, Hanwen; Morgenstern, Alfred; Bruchertseifer, Frank; Boisclair, Julie; Provencher-Bolliger, Anne; Reubi, Jean-Claude; Maecke, Helmut R (2011). Alpha- versus beta-particle radiopeptide therapy in a human prostate cancer model (213Bi-DOTA-PESIN and 213Bi-AMBA versus 177Lu-DOTA-PESIN). Cancer research, 71(3), pp. 1009-18. Birmingham, Ala.: American Association for Cancer Research AACR 10.1158/0008-5472.CAN-10-1186
Fani, Melpomeni; Mueller, Andreas; Tamma, Maria-Luisa; Nicolas, Guillaume; Rink, Hans R; Cescato, Renzo; Reubi, Jean-Claude; Maecke, Helmut R (2010). Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors. Journal of nuclear medicine, 51(11), pp. 1771-9. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.110.076695
Waser, Beatrice; Cescato, Renzo; Tamma, Maria-Luisa; Maecke, Helmut R; Reubi, Jean-Claude (2010). Absence of somatostatin SST(2) receptor internalization in vivo after intravenous SOM230 application in the AR42J animal tumor model. European journal of pharmacology, 644(1-3), pp. 257-62. Amsterdam: Elsevier 10.1016/j.ejphar.2010.07.005
Abiraj, Keelara; Mansi, Rosalba; Tamma, Maria-Luisa; Forrer, Flavio; Cescato, Renzo; Reubi, Jean-Claude; Akyel, Kayhan G; Maecke, Helmut R (2010). Tetraamine-derived bifunctional chelators for technetium-99m labelling: synthesis, bioconjugation and evaluation as targeted SPECT imaging probes for GRP-receptor-positive tumours. Chemistry - a European journal, 16(7), pp. 2115-24. Weinheim: Wiley-VCH 10.1002/chem.200902011
Mansi, Rosalba; Wang, Xuejuan; Forrer, Flavio; Kneifel, Stefan; Tamma, Maria-Luisa; Waser, Beatrice; Cescato, Renzo; Reubi, Jean-Claude; Maecke, Helmut R (2009). Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides. Clinical cancer research, 15(16), pp. 5240-9. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-08-3145
Waser, Bea; Tamma, Maria-Luisa; Cescato, Renzo; Maecke, Helmut R; Reubi, Jean-Claude (2009). Highly efficient in vivo agonist-induced internalization of sst2 receptors in somatostatin target tissues. Journal of nuclear medicine, 50(6), pp. 936-41. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.108.061457
Reubi, Jean-Claude; Maecke, Helmut R (2008). Peptide-based probes for cancer imaging. Journal of nuclear medicine, 49(11), pp. 1735-8. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.108.053041
Good, Stephan; Walter, Martin A; Waser, Beatrice; Wang, Xuejuan; Müller-Brand, Jan; Béhé, Martin P; Reubi, Jean-Claude; Maecke, Helmut R (2008). Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours. European journal of nuclear medicine and molecular imaging, 35(10), pp. 1868-77. Berlin: Springer 10.1007/s00259-008-0803-4
Ginj, Mihaela; Zhang, Hanwen; Eisenwiener, Klaus-Peter; Wild, Damian; Schulz, Stefan; Rink, Hans; Cescato, Renzo; Reubi, Jean Claude; Maecke, Helmut R (2008). New pansomatostatin ligands and their chelated versions: affinity profile, agonist activity, internalization, and tumor targeting. Clinical cancer research, 14(7), pp. 2019-27. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-07-1687
Heppeler, Axel; André, João P; Buschmann, Ingeborg; Wang, Xuejuan; Reubi, Jean-Claude; Hennig, Michael; Kaden, Thomas A; Maecke, Helmut R (2008). Metal-ion-dependent biological properties of a chelator-derived somatostatin analogue for tumour targeting. Chemistry - a European journal, 14(10), pp. 3026-34. Weinheim: Wiley-VCH 10.1002/chem.200701264
Cescato, Renzo; Erchegyi, Judith; Waser, Beatrice; Piccand, Véronique; Maecke, Helmut R; Rivier, Jean E; Reubi, Jean Claude (2008). Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. Journal of medicinal chemistry, 51(13), pp. 4030-7. Easton, Pa.: American Chemical Society 10.1021/jm701618q
Zhang, Hanwen; Schuhmacher, Jochen; Waser, Beatrice; Wild, Damian; Eisenhut, Michael; Reubi, Jean Claude; Maecke, Helmut R (2007). DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours. European journal of nuclear medicine and molecular imaging, 34(8), pp. 1198-208. Berlin: Springer 10.1007/s00259-006-0347-4
Antunes, Patricia; Ginj, Mihaela; Walter, Martin A; Chen, Jianhua; Reubi, Jean-Claude; Maecke, Helmut R (2007). Influence of different spacers on the biological profile of a DOTA-somatostatin analogue. Bioconjugate chemistry, 18(1), pp. 84-92. Washington, D.C.: American Chemical Society 10.1021/bc0601673
Ginj, Mihaela; Schmitt, Jörg S; Chen, Jianhua; Waser, Beatrice; Reubi, Jean-Claude; de Jong, Marion; Schulz, Stefan; Maecke, Helmut R (2006). Design, synthesis, and biological evaluation of somatostatin-based radiopeptides. Chemistry & biology, 13(10), pp. 1081-90. San Francisco, Calif.: Current Biology Ltd. 10.1016/j.chembiol.2006.08.012
Kneifel, Stefan; Cordier, Dominik; Good, Stephan; Ionescu, Mihai C S; Ghaffari, Anthony; Hofer, Silvia; Kretzschmar, Martin; Tolnay, Markus; Apostolidis, Christos; Waser, Beatrice; Arnold, Marlene; Mueller-Brand, Jan; Maecke, Helmut R; Reubi, Jean Claude; Merlo, Adrian (2006). Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance p. Clinical cancer research, 12(12), pp. 3843-50. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-05-2820
